Tumor rejection by gene transfer of the MHC class II transactivator in murine mammary adenocarcinoma cells
نویسندگان
چکیده
منابع مشابه
PML promotes MHC class II gene expression by stabilizing the class II transactivator
Promyelocytic leukemia (PML) nuclear bodies selectively associate with transcriptionally active genomic regions, including the gene-rich major histocompatibility (MHC) locus. In this paper, we have explored potential links between PML and interferon (IFN)-γ-induced MHC class II expression. IFN-γ induced a substantial increase in the spatial proximity between PML bodies and the MHC class II gene...
متن کاملIL-1b Inhibits IFN-g-Induced Class II MHC Expression by Suppressing Transcription of the Class II Transactivator Gene
متن کامل
CIITA-induced MHC class II expression in mammary adenocarcinoma leads to a Th1 polarization of the tumor microenvironment, tumor rejection, and specific antitumor memory.
PURPOSE We have shown previously that the MHC class II-negative murine TS/A adenocarcinoma is rejected in vivo if induced to express MHC class II molecules by transfection of the MHC class II transactivator CIITA. In this study, we explored the immunologic basis of tumor rejection and the correlation between histopathology of tumor tissue and immune rejection. EXPERIMENTAL DESIGN Stable TS/A-...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2003
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200323712